Rung 3 · Moderate
Aspirin for people with Lynch syndrome
Fewer colorectal cancers in one randomized trial, appearing years later.
PreventionWith your doctorSafety flag
Safety: Daily aspirin raises the risk of bleeding in the stomach and intestines and of stroke.
What studies found
In the CAPP2 trial, 861 people with Lynch syndrome took 600 mg of aspirin or a placebo daily for 2 to 4 years. Over 10 to 20 years of follow-up, 40 developed colorectal cancer in the aspirin group and 58 in the placebo group, about half the risk.
The catch
One trial, at a high dose, with the benefit appearing only years later.
What to do
Consider it only with your genetics team, who can weigh it against bleeding risk.
Sources
Rung 3 of 5, Moderate: Consistent observational studies or small trials, not yet confirmed by large trials. How we score
To take it to your doctor, print this page.
Step by step
For the whole picture, from prevention and screening to treatment and life after, see the colorectal cancer page.
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