Stool DNA or RNA test every 3 years
Finds more than FIT, with more false alarms.
What studies found
A stool DNA test combined with FIT finds about 93% of colorectal cancers and 43% of advanced precancerous polyps, with a specificity of 84% (U.S. Task Force pooled data). The American Cancer Society's 2026 update lists stool DNA (Cologuard) and the newer stool RNA test (ColoSense) every 3 years; the Task Force says every 1 to 3 years for stool DNA.
The catch
No trial has shown that this test on its own lowers deaths; its benefit is inferred from its accuracy.
What to do
Repeat every 3 years, and have a colonoscopy within 6 months if it's positive.
Sources
Rung 4 of 5, Strong: At least one large randomized trial, or very large consistent studies, on this exact question. How we score
Step by step
For the whole picture, from prevention and screening to treatment and life after, see the colorectal cancer page.
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